CANCER-ASSOCIATED RETINOPATHY WITH RETINAL PHLEBITIS

A 50-year-old man with cancer-associated retinopathy was investigated using light and electron microscopy, immunofluorescence studies, and w estern blotting. He had visual disturbance, ring-like scotoma, and nig ht blindness bilaterally. There were narrowed retinal arterioles and d ilated retinal venules. Oral corticosteroid therapy had positive effec ts. Immunostaining using the patient's serum revealed a positive react ion in the ganglion cell layer of normal retina. Western blotting show ed that the patient's serum antibody reacted with normal retinal prote ins of 24 and 48 kDa. Multiple metastases were evident at autopsy.