The social network paradigm provides a set of concepts and methods use
ful for studying the structure of a population through which infectiou
s agents transmitted during close personal contact spread, and an oppo
rtunity to develop improved disease control programs. The research dis
cussed was a first attempt to use a social network approach to better
understand factors affecting the transmission of a variety of pathogen
s, including hepatitis B virus (HBV) and human immunodeficiency viruse
s (HIV), in a population of prostitutes, injecting drug users (IDU) an
d their personal associates in a moderate-sized city (Colorado Springs
, CO). Some of the challenges of studying large social networks in epi
demiological research are described, some initial results reported and
a new view of interconnections in an at risk population provided. Ove
rall, for the first time in epidemiologic research a large number of i
ndividuals (over 600) were found connected to each other, directly or
indirectly, using a network design. The average distance (along observ
ed social relationships) between persons infected with HIV and suscept
ible persons was about three steps (3.1) in the core network region. A
ll susceptibles in the core were within seven steps of HIV infection.