TAU AS A MARKER FOR ALZHEIMERS-DISEASE

Citation
Em. Mandelkow et E. Mandelkow, TAU AS A MARKER FOR ALZHEIMERS-DISEASE, Trends in biochemical sciences, 18(12), 1993, pp. 480-483
Citations number
46
Categorie Soggetti
Biology
ISSN journal
09680004
Volume
18
Issue
12
Year of publication
1993
Pages
480 - 483
Database
ISI
SICI code
0968-0004(1993)18:12<480:TAAMFA>2.0.ZU;2-Y
Abstract
Alzheimer's Disease (AD) is an age-related dementia that has received increasing attention in recent years. The disease appears to be specif ic for humans and, moreover, its causes are unknown. Studies of the di sease are complicated by the fact that a reliable diagnosis depends on post-mortem analysis of brain tissue, and useful animal or cell model s are not yet available. This article discusses the possibility of usi ng tau (a protein associated with the neurofibrillary tangles that are an indicator of AD) as a tool for further pursuing the diagnosis and treatment of the disease.