THE DISTRIBUTION OF HLA DQA1 AND D1S80 (PMCT118) ALLELES AND GENOTYPES IN THE POPULATIONS OF GALICIA AND CENTRAL PORTUGAL

Two South-West European populations (Galicia and Central Portugal) hav e been studied for the HLA DQA1 and D1S80 systems. The allele and geno type frequencies found have been compared with other previously publis hed data. The distribution of the observed genotypes is in Hardy-Weinb erg equilibrium for both systems. In the D1S80 system, no significant differences were found between both populations, although in the HLA D QA1 system the allele DQA10301 is twice as frequent in the Galician p opulation. Other populations that have been compared showed a certain degree of divergence for the HLA DQA1 system. The combined chance of e xclusion for both systems is 0.84 in Galicia and 0.85 in Central Portu gal, and the combined power of discrimination is 0.993 in the 2 popula tions studied.