PROGNOSTIC-SIGNIFICANCE OF THE STRUCTURE OF CHROMOSOMAL TRANSLOCATION-T (9 22) LOCUS IN CHRONIC MYELOID-LEUKEMIA

Authors
TURKINA AG DOMNINSKY DA POKROVSKAYA YS BABUSHKINA YA MOISEENKOVA IN ZAKHAROVA AV ARKHIPOVA NV GRINEVA NI KHOROSHKO ND
Citation
Ag. Turkina et al., PROGNOSTIC-SIGNIFICANCE OF THE STRUCTURE OF CHROMOSOMAL TRANSLOCATION-T (9 22) LOCUS IN CHRONIC MYELOID-LEUKEMIA, Gematologia i transfuziologia, 38(3), 1993, pp. 8-11
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Gematologia i transfuziologia → ACNP
ISSN journal
02345730
Volume
38
Issue
3
Year of publication
1993
Pages
8 - 11
Database
ISI
SICI code
0234-5730(1993)38:3<8:POTSOC>2.0.ZU;2-2
Abstract
The site of the break of chromosome 22 was investigated by blot hybrid ization and polymerase chain reaction in 41 patients with chronic myel oid leukemia (CML). It is stated that the break site in various region s is not associated with the disease stage and clinicohematological ma nifestations in the time of the diagnosis. The break in the 5' subregi on was indicative of longer survival than that in the subregion 3' pat ients. Median survival reached 60.8 and 32.4 months, respectively.