THE EFFECT OF RECOMBINANT-HUMAN-ERYTHROPO IETIN ON LIPID-PEROXIDATIONAND RED-CELL ANTIOXIDANT RESISTANCE IN HEMODIALYSIS CHRONICS WITH RENAL-FAILURE

Twenty patients with terminal-stage chronic renal failure (CRF) underw ent long-term hemodialysis. Ten of them (group 1) did not receive huma n erythropoietin (HEP), four patients (group 2) received HEP for 1 mon th, six patients (group 3) for 12 months. Group 3 patients exhibited a marked increase in Hb, hematocrit, red cell number, while serum Fe wa s reduced. MDA rose in group 1 by 34 % (p<0.05), in group 2 by 199 % ( p<0.05), was normal in group 3. Red cell catalase and glutathione pero xidase activities were normal. The results evidence that 1-month HEP t reatment enhances oxidant degradation of erythrocytic membrane lipids. Lipid peroxidation becomes normal to the end of 1-year HEP treatment despite low SOD activity. Application of HEP in CRF patients is advisa ble to combine with antioxidant modalities to intensify red cell resis tance to hemodialysis.