THE HUMAN PHENOLSULFOTRANSFERASE POLYMORPHISM IS DETERMINED BY THE LEVEL OF EXPRESSION OF THE ENZYME PROTEIN

Authors
JONES AL ROBERTS RC COUGHTRIE MWH
Citation
Al. Jones et al., THE HUMAN PHENOLSULFOTRANSFERASE POLYMORPHISM IS DETERMINED BY THE LEVEL OF EXPRESSION OF THE ENZYME PROTEIN, Biochemical journal, 296, 1993, pp. 287-290
Citations number
31
Categorie Soggetti
Biology
Journal title
Biochemical journal → ACNP
ISSN journal
02646021
Volume
296
Year of publication
1993
Part
2
Pages
287 - 290
Database
ISI
SICI code
0264-6021(1993)296:<287:THPPID>2.0.ZU;2-Z
Abstract
We have examined the expression of platelet phenolsulphotransferase (P ST) in 60 individuals. Using an antibody which recognizes both forms o f PST present in man (P-PST and M-PST), we determined that the polymor phism of platelet P-PST activity is determined by the level of express ion of the enzyme protein. The implications for susceptibility to adve rse drug reactions and chemical carcinogenesis are discussed.