FAST F-19-NMR IMAGING IN-VIVO USING FLASH-MRI

The goal of this study was the development of a method that allows the acquisition of chemical shift selective F-39 NMR images within a shor t measuring time. A train of small tip angle frequency selective pulse s, each followed by a dephasing gradient of random strength, was used as a presaturation experiment for the suppression of the unwanted chem ical shift components. Imaging was performed after presaturation using a SNAPSHOT-FLASH experiment. The acquisition time for a 64 x 128 imag e including the presaturation experiment amounted to only 470 ms. The sequence was applied in a 4.7 Tesla magnet to perform a longitudinal p harmacological study on the clearance of perfluorooctylbromide (PFOB) in the liver and spleen of rats.