The goal of this study was the development of a method that allows the
acquisition of chemical shift selective F-39 NMR images within a shor
t measuring time. A train of small tip angle frequency selective pulse
s, each followed by a dephasing gradient of random strength, was used
as a presaturation experiment for the suppression of the unwanted chem
ical shift components. Imaging was performed after presaturation using
a SNAPSHOT-FLASH experiment. The acquisition time for a 64 x 128 imag
e including the presaturation experiment amounted to only 470 ms. The
sequence was applied in a 4.7 Tesla magnet to perform a longitudinal p
harmacological study on the clearance of perfluorooctylbromide (PFOB)
in the liver and spleen of rats.