SYNTHESIS AND MUSCARINIC ACTIVITY OF SOME MUSCARONE ANALOGS

Authors
DEMICHELI C DEAMICI M GRANA E ZONTA F GIANNELLA M PIERGENTILI A
Citation
C. Demicheli et al., SYNTHESIS AND MUSCARINIC ACTIVITY OF SOME MUSCARONE ANALOGS, Il Farmaco, 48(10), 1993, pp. 1333-1348
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
10
Year of publication
1993
Pages
1333 - 1348
Database
ISI
SICI code
0014-827X(1993)48:10<1333:SAMAOS>2.0.ZU;2-0
Abstract
The synthesis of some muscarone analogs has been accomplished and thei r muscarinic activity has been assayed in three in vitro functional te sts. The results of such an investigation put in evidence the active r ole played by the methylene moiety, placed exocyclic to the pentaatomi c ring, on the interaction of the ligands with the different muscarini c receptor subtypes. Worth noting is the ileum-atria selectivity displ ayed by methylene derivative 7.