SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF A NEW CLASS OF 2-OXO-8-AZASPIRO (4,5)DECAN-1-ONES AS ANALOGS OF THE MUSCARINIC AGONIST RS-86

Authors
CIGNARELLA G VILLA S BARLOCCO D
Citation
G. Cignarella et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF A NEW CLASS OF 2-OXO-8-AZASPIRO (4,5)DECAN-1-ONES AS ANALOGS OF THE MUSCARINIC AGONIST RS-86, Il Farmaco, 48(10), 1993, pp. 1439-1445
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
10
Year of publication
1993
Pages
1439 - 1445
Database
ISI
SICI code
0014-827X(1993)48:10<1439:SAPEOA>2.0.ZU;2-W
Abstract
A new series of 8-substituted-2-oxo-8-azapsiro (4,5)decan-1-ones has b een synthesized and compounds tested for their cholinergic properties in comparison with the muscarinic agonist RS-86. Preliminary in vitro and in vivo pharmacological data indicate that none of them is provide d with significant cholinergic effects either at central or peripheral level. A possible explanation for the lack of activity is given on th e basis of conformational studies.