DOXORUBICIN ALONE OR IN COMBINATION WITH ASPARAGINASE, FOLLOWED BY CYCLOPHOSPHAMIDE, VINCRISTINE, AND PREDNISONE FOR TREATMENT OF MULTICENTRIC LYMPHOMA IN DOGS - 121 CASES (1987-1995)
Kd. Valerius et al., DOXORUBICIN ALONE OR IN COMBINATION WITH ASPARAGINASE, FOLLOWED BY CYCLOPHOSPHAMIDE, VINCRISTINE, AND PREDNISONE FOR TREATMENT OF MULTICENTRIC LYMPHOMA IN DOGS - 121 CASES (1987-1995), Journal of the American Veterinary Medical Association, 210(4), 1997, pp. 512
Objective--To determine response rate and remis sion as well as surviv
al times far dogs with multicentric lymphoma treated first with doxoru
bicin alone or in combination with asparaginase and then with cyclopho
sphamide, vincristine sulfate, and prednisone (CVP) and to identify pr
evalence of toxicoses associated with this protocol and factors associ
ated with prognosis; Design-Retrospective case series, Animals--121 do
gs. Procedure--Variables evaluated for prognostic value were initial r
esponse rate to chemotherapy, age, breed, sex, body weight, histologic
grade, clinical stage and substage, previous corticosteroid treatment
, and serum calcium concentration. Results--Median overall remission a
nd survival times for all 121 dogs were 205 and 237 days, respectively
. Response rate (complete or partial response) was 88%. Ten dogs were
hospitalized because of toxicoses associated with doxorubicin, and 19
dogs were hospitalized because of toxicoses associated with CVP. Aspar
aginase favorably influenced the initial response rate, but did not si
gnificantly influence overall remission or survival times. initial res
ponse rate to chemotherapy, body weight, clinical substage, and serum
calcium concentration was found to have prognostic value. Clinical Imp
lications--For dogs with multicentric lymphoma, treatment with doxorub
icin alone or in combination with asparaginase and then with CVP resul
ted in an acceptable response rate and low prevalence of toxicoses.