PURPOSE: The high mortality associated with ileosigmoid knotting promp
ted us to review the collected experiences of three university hospita
ls in order to establish a more rational approach to the problem. METH
OD: The clinical records of 68 patients with ileosigmoid knotting from
1970 to 1990 were reviewed with respect to incidence, etiopathogenesi
s, clinical features, treatment, and clinical outcome. RESULTS: The mo
st common type of ileosigmoid knotting was Type IA (48.5 percent), in
which the active ileum encircled the passive sigmoid in a clockwise ma
nner. Fifty (73.5 percent) patients developed a gangrenous bowel where
as 18 patients did not show any definite evidence of impairment of bow
el viability. En bloc removal of gangrenous knot and reestablishment o
f intestinal continuity by enteroenteric or enterocolic anastomosis co
mbined with the Hartmann procedure, which was employed in 20 (42.6 per
cent) cases, constituted the most frequently preferred operation. The
mortality rate in this series was 30.9 percent (21/68) and toxic shock
, which ultimately resulted in multiple organ failure, was the major c
ause of death. It was remarkable to note that there was an inverse cor
relation between the duration of symptoms and the mortality rate refle
cting the dramatic rapidity and severity of symptoms due to tightness
of the knot which led to early and extensive gangrene, thus inevitably
urged the patients to seek medical help without delay. CONCLUSION: Th
e performance of prompt, individualized surgical treatment in conjunct
ion with the use of advanced measures of critical care to combat the d
isastrous consequences of multiple organ failure would contribute grea
tly to improve survival rate in victims of this dreadful entity.