THE EFFECT OF LONG-TERM METHOTREXATE THERAPY ON HEPATIC-FIBROSIS IN RHEUMATOID-ARTHRITIS

Authors
BJORKMAN DJ BOSCHERT M TOLMAN KG CLEGG DO WARD JR
Citation
Dj. Bjorkman et al., THE EFFECT OF LONG-TERM METHOTREXATE THERAPY ON HEPATIC-FIBROSIS IN RHEUMATOID-ARTHRITIS, Arthritis and rheumatism, 36(12), 1993, pp. 1697-1701
Citations number
10
Categorie Soggetti
Rheumatology
Journal title
Arthritis and rheumatism → ACNP
ISSN journal
00043591
Volume
36
Issue
12
Year of publication
1993
Pages
1697 - 1701
Database
ISI
SICI code
0004-3591(1993)36:12<1697:TEOLMT>2.0.ZU;2-1
Abstract
Objective. To evaluate the progression of hepatic fibrosis in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). Metho ds. Fifteen patients receiving MTX for RA were prospectively studied b y electron microscopic analysis of biopsy specimens. Results. Five of the 15 patients had evidence of increased hepatic collagen after 2 yea rs of MTX therapy. Conclusion. Hepatic fibrosis may progress in a subg roup of RA patients treated with MTX.