ROTHMUND-THOMSON SYNDROME AND OSTEOSARCOMA

Authors
JUDGE MR KILBY A HARPER JI
Citation
Mr. Judge et al., ROTHMUND-THOMSON SYNDROME AND OSTEOSARCOMA, British journal of dermatology, 129(6), 1993, pp. 723-725
Citations number
15
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
British journal of dermatology → ACNP
ISSN journal
00070963
Volume
129
Issue
6
Year of publication
1993
Pages
723 - 725
Database
ISI
SICI code
0007-0963(1993)129:6<723:RSAO>2.0.ZU;2-4
Abstract
A 10-year-old girl with Rothmund-Thomson syndrome developed a fibular osteosarcoma. Standard chemotherapy produced intolerable toxicity, nec essitating a modification of therapy. Initial DNA repair studies on sk in fibroblasts were abnormal, but repeat studies failed to reproduce t he defects.