E. Mathiowitz et al., MORPHOLOGICAL CHARACTERIZATION OF BIOERODIBLE POLYMERS .2. CHARACTERIZATION OF POLYANHYDRIDES BY FOURIER-TRANSFORM INFRARED-SPECTROSCOPY, Macromolecules, 26(25), 1993, pp. 6749-6755
This paper describes the Fourier-transform infrared (FTIR) spectroscop
y of a series of polyanhydrides made of the following diacids: sebacic
acid (SA); 1,3-bis(p-carboxyphenoxy)propane (CPP); 1,6-bis(p-carboxyp
henoxy)hexane (CPH); (carboxyphenoxy)methane (CPM); fumaric acid (FA);
5-(P-carboxyphenoxy)valeric acid (CPV). All the polymers revealed typ
ical anhydride peaks corresponding to aliphatic-aliphatic, aliphatic-a
romatic, and aromatic-aromatic diads in the wavenumber range 1820-1710
cm-1. Additional paired peaks corresponding to SA-SA diads were ident
ified in the fingerprint region at 1382, 1360 and 1307, 1286 cm-1. The
second pair was assigned to the crystalline regions of the copolymers
. This information allows easy identification of bond distribution in
a variety of polyanhydrides, and correlates well with information prev
iously presented using nuclear magnetic resonance (NMR) spectroscopy a
nd X-ray powder diffraction.