ELECTROCHEMICAL-BEHAVIOR OF CHLORPROMAZINE

Oxidation of chlorpromazine at a phospholipid modified glassy carbon e lectrode has been determined from analysis of voltamperometric curves. Measurements realized using the preconcentration technique allow inte resting sensitivity improvements. The oxidation current is increased b y six-fold over that in the absence of lipid. The electrode response i s pH-dependent. A shift of only 10 mV was found for the peak potential s with respect to the value obtained at an unmodified electrode. Inter actions between the chlorpromazine oxidised product and the lipid laye r are discussed.