Jj. Gerber et al., STRUCTURES OF 2 CONFORMATIONAL POLYMORPHS OF THE CHOLESTEROL-LOWERINGDRUG PROBUCOL, Journal of crystallographic and spectroscopic research, 23(11), 1993, pp. 863-869
Two polymorphic forms of the drug probucol, (4,4'-[(1-Methylethylidene
)-bis(thio)]bis-[2,6-bis (1, 1-dimethylethyl)phenol]), have been isola
ted and characterized by thermal analysis, X-ray powder diffraction an
d single crystal X-ray analyses. Form I, with onset melting point 125-
degrees-C, is monoclinic, space group P2(1)/c with a = 16.972(5), b =
10.534(4), c = 19.03(1) angstrom, beta = 113.66(3)-degrees, Z = 4. For
m II, with onset melting temperature 116-degrees-C, is monoclinic, spa
ce group P2(1)/n with a = 11.226(2), b = 15.981(2), c = 18.800(3) angs
trom, beta = 104.04(1)-degrees, Z = 4. The probucol molecule adopts di
fferent conformations in the two polymorphs. In Form II, the C-S-C-S-C
chain is extended and the molecular symmetry approximates C2v whereas
in Form I, the two S-C-S-C torsion angles are approximately 80-degree
s and 165-degrees. Molecular mechanics calculations show that the less
symmetrical conformer of Form I is more stable than the conformer in
Form II by approximately 26 kJ mol-1. Crystal packing in both polymorp
hs is determined by van der Waals interactions only. X-ray powder diff
raction indicates that Form II converts to Form I on grinding.