Regional spinal cord blood flow was measured in rats during the sleep-
wake cycle with the use of radioactive microspheres. Spinal cord blood
flow decreases from wakefulness to quiet (synchronized) sleep while i
ncreasing in active (desynchronized) sleep. Blood-flow changes depend
on changes in vascular resistance whose mechanisms have yet to be eluc
idated. Blood-gas tension or mean arterial pressure, however, do not p
lay a relevant causal role.