S. Demarchi et al., RENAL TUBULAR DYSFUNCTION IN CHRONIC ALCOHOL-ABUSE - EFFECTS OF ABSTINENCE, The New England journal of medicine, 329(26), 1993, pp. 1927-1934
Background. Alcohol abuse may be accompanied by a variety of disorders
of electrolyte and acid-base metabolism. The role of the kidney in th
e pathogenesis of these disturbances is obscure. We sought to evaluate
the alcohol-induced abnormalities of renal function and improvement d
uring abstinence and to assess the relation between renal dysfunction
and electrolyte and acid-base disorders.Methods. We measured biochemic
al constituents of blood and renal function before and after four week
s of abstinence in 61 patients with chronic alcoholism who had little
or no liver disease. Results. On admission, 18 patients (30 percent) h
ad hypophosphatemia and hypomagnesemia, 13 patients (21 percent) had h
ypocalcemia, and 8 patients (13 percent) had hypokalemia. Twenty-two p
atients (36 percent) had a variety of simple and mixed acid-base disor
ders. Twenty of these patients had metabolic acidosis, and among them,
80 percent had alcoholic acidosis. A wide range of defects in renal t
ubular function, with normal glomerular filtration rate, was detected
in these patients. The defects included decreases in the threshold and
maximal reabsorptive ability for glucose (38 percent of patients) and
in the renal threshold for phosphate excretion (36 percent); increase
s in the fractional excretion of beta2-microglobulin (38 percent), uri
c acid (12 percent), calcium (23 percent), and magnesium (21 percent);
and aminoaciduria (38 percent). Seventeen patients (28 percent) had a
defect in tubular acidification, and five an impairment in urinary co
ncentrating ability. Urinary excretion of N-acetyl-beta-D-glucosaminid
ase and alanine aminopeptidase was increased in 41 and 34 percent of p
atients, respectively. The abnormalities of blood chemistry and renal
tubular function disappeared after four weeks of abstinence. Conclusio
ns. Transient defects in renal tubular function are common in patients
with chronic alcoholism and may contribute to their abnormalities of
serum electrolyte and blood acid-base profiles.