PHARMACOLOGICAL STUDIES ON HUMAN URINARY KALLIDINOGENASE (SK-827) - CEREBRAL PROTECTIVE EFFECTS

We investigated the cerebral protective effects of human urinary kalli dinogenase (SK-827) in rabbits. The following results were obtained: 1 ) At a dose of 5.0x10(-3) to 1.25X10(-2) PNA. U/kg, SK-827 significant ly inhibited the decrease of focal cerebral blood flow and the impairm ent of electrocorticogram (ECoG) activity in infarcted rabbits. 2) SK- 827 at a dose of 2.5X10(-3) PNA U/kg inhibited the development of infa rction area induced by internal carotid arterial injection of glass be ads. 3) SK-827 at a dose of 2.5X10(-3) to 5.0X10(-3) PNA U/kg inhibite d the decrease of cerebral cortical pO(2) induced by 5% oxygen inhalat ion. 4) On subacute phase 7 days after the destruction of internal cap sule, SK-827 at a dose of 1.25X10(-2) PNA U/kg improved the abnormalit y of spontaneous ECoG. These findings suggest that SK-827 minimizes th e reduction of cerebral function induced by ischemia.