PHARMACOLOGICAL STUDIES ON HUMAN URINARY KALLIDINOGENASE (SK-827) - EFFECTS ON CEREBRAL METABOLISM

Authors
NAGANO H SUZUKI T TOMOGURI T HAYASHI M TSURUMI K
Citation
H. Nagano et al., PHARMACOLOGICAL STUDIES ON HUMAN URINARY KALLIDINOGENASE (SK-827) - EFFECTS ON CEREBRAL METABOLISM, Yakugaku zasshi, 113(11), 1993, pp. 825-828
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Yakugaku zasshi → ACNP
ISSN journal
00316903
Volume
113
Issue
11
Year of publication
1993
Pages
825 - 828
Database
ISI
SICI code
0031-6903(1993)113:11<825:PSOHUK>2.0.ZU;2-4
Abstract
We investigated the effects of human urinary kallidinogenase (SK-827) on cerebral metabolism in normal and infarcted rabbits. SK-827 did not influence cerebral glucose and oxygen uptake in normal rabbits. In in farcted rabbits, cerebral glucose and oxygen uptake significantly decr eased. SK-827 tended to inhibit the decrease of cerebral blood flow, a nd significantly inhibited the decrease of cerebral glucose and oxygen uptake in infarcted rabbits. Thus, SK-827 improved cerebral glucose m etabolism in infarcted rabbits.