24-HOUR PATTERN OF ATRIAL-NATRIURETIC-PEPTIDE IN HEART-TRANSPLANTATION - EVIDENCE FOR LACK OF CIRCADIAN-RHYTHM - TEMPORAL INTERRELATIONSHIPS WITH PLASMA-RENIN ACTIVITY, ALDOSTERONE AND CORTISOL
P. Cugini et al., 24-HOUR PATTERN OF ATRIAL-NATRIURETIC-PEPTIDE IN HEART-TRANSPLANTATION - EVIDENCE FOR LACK OF CIRCADIAN-RHYTHM - TEMPORAL INTERRELATIONSHIPS WITH PLASMA-RENIN ACTIVITY, ALDOSTERONE AND CORTISOL, International journal of cardiology, 42(1), 1993, pp. 7-14
We have investigated the circadian rhythm of plasma atrial natriuretic
peptide in 13 stable output heart transplanted patients, all without
evidence of histological rejection and cardiac impairment, following a
ntirejection therapy with Cyclosporine, Azathioprine and Prednisone. T
he 24-h pattern of plasma renin activity, plasma aldosterone and plasm
a cortisol has been studied as well. All the investigated variables we
re assayed six times over the 24-h span. The circadian time-qualified
data were analyzed by ANOVA and Cosinor method. The 24-h mean levels o
f atrial natriuretic peptide, plasma renin activity and plasma aldoste
rone are significantly increased, while the concentrations of plasma c
ortisol are reduced in the heart transplanted recipients. ANOVA detect
ed a significant within-day variability of all these humoral variables
only in healthy subjects. A statistically significant circadian rhyth
m was validated by Cosinor procedure for all the investigated molecule
s in healthy subjects but not in heart transplanted patients. In our o
pinion, the increase of atrial natriuretic peptide is a counterregulat
ory mechanism aimed to compensate the cyclosporine-mediated activation
of the renin-angiotensin-aldosterone system. The disappearance of the
plasma renin activity, aldosterone and atrial natriuretic peptide cir
cadian rhythm can be ascribed to the constant activation of the renin-
angiotensin-aldosterone system. The hypocortisolism is due, in our opi
nion, both to glucocorticoid therapy and increase of plasma ANP concen
tration.