G. Derosa et al., SUCCESSFUL TREATMENT OF ECTOPIC CUSHINGS-SYNDROME WITH THE LONG-ACTING SOMATOSTATIN ANALOG OCTREOTIDE, Experimental and clinical endocrinology, 101(5), 1993, pp. 319-325
We report on the efficacy of the long-acting somatostatin analog octre
otide in a 43-yr old woman with ectopic ACTH syndrome. Plasma cortisol
, ACTH, beta-endorphin (beta-END) and urinary free cortisol (UFC) were
elevated (range 743-920 nmol/l, 29.2-49.7 pmol/l, 71.0-84.1 pmol/l, 2
117-3119 nmol/day respectively). Ovine CRH (oCRH) and high dose dexame
thasone did not affect cortisol and ACTH levels, while UFC significant
ly decreased after dexamethasone. Initially radiological investigation
failed to localize the ACTH secreting tumor. Ketoconazole was not tol
erated. Plasma cortisol significantly decreased both after single (100
mug sc) (baseline 531 nmol/l, nadir 218 nmol/l) and 3-day octreotide
administration (from 810 to 448 nmol/l); plasma ACTH decreased slightl
y (from 30.4 to 21.3 pmol/l and from 32.4 to 22.5 pmol/l respectively)
; UFC decreased from 2616 to 711 nmol/day after the 3-day test. Long-t
erm octreotide treatment (100 mug/8h per 54 weeks) led to clinical and
biochemical improvement and recurrence followed drug withdrawal; no s
ide effects were observed. Six months after octreotide administration
a 2 cm lung mass was detected with CT and MR. Surgery was performed an
d a bronchial carcinoid was removed. Immunoreactive ACTH in the tumor
has been demonstrated by histochemistry. Postoperatively a lasting rem
ission of Cushing's syndrome was observed without further therapy.