P. Thomas et al., ACUTE AND CHRONIC EFFECTS OF FLOSEQUINAN ON RESTING AND EXERCISE HEMODYNAMICS IN CONGESTIVE-HEART-FAILURE, British journal of clinical pharmacology, 36(6), 1993, pp. 539-546
1 The acute and chronic (8 weeks) haemodynamic responses to oral flose
quinan have been investigated in 12 male patients of mean age 58.9 yea
rs with congestive heart failure of N.Y.H.A. classes II and III. 2 Flo
sequinan 125 mg orally significantly reduced right atrial pressure, pu
lmonary artery pressure and pulmonary wedge pressure prior to and foll
owing 8 weeks chronic treatment (125 mg daily). A significant decrease
in systemic pressure and an increase in heart rate were also observed
with acute flosequinan prior to chronic treatment. A reduction in sys
temic vascular resistance and an increase in cardiac index reached sig
nificance in response to flosequinan 125 mg orally following 8 weeks o
f therapy. 3 In the erect position, flosequinan reduced pulmonary wedg
e pressure and tended to reduce systemic vascular resistance, without
decreasing mean arterial pressure. 4 Following chronic treatment, ther
e was a trend towards a reduction in pulmonary wedge pressure and an i
ncrease in cardiac index, otherwise resting and exercise haemodynamics
were unchanged. 5 The response to flosequinan was similar at week 1 a
nd after 8 weeks of treatment for all of the haemodynamic parameters.
6 Flosequinan increased bicycle exercise times and attenuated exercise
-induced increases in pulmonary arterial and systemic pressures. There
was a trend towards an increase in treadmill exercise time. 7 Subling
ual glyceryl trinitrate (0.5 mg) and oral flosequinan (125 mg) had sim
ilar effects on right atrial pressure, pulmonary arterial and pulmonar
y wedge pressures at 5 min and 2 h respectively post-dosing. A small a
dditive effect on pulmonary arterial and wedge pressures was observed.