ORAL BROMFENAC 10 AND 25 MG COMPARED WITH SUBLINGUAL BUPRENORPHINE 0.2 AND 0.4 MG FOR POSTOPERATIVE PAIN RELIEF

The aim of this single-dose, randomized positive control, double-dummy , double-blind parallel group study was to compare oral bromfenac 10 a nd 25 mg with sublingual buprenorphine 0.2 and 0.4 mg for treatment of postoperative pain. We studied 91 patients with moderate or severe pa in after general surgical or orthopaedic operations, using pain intens ity, pain relief, adverse effect, mood and sedation outcomes. There wa s a significant analgesic dose-response for buprenorphine, showing stu dy sensitivity, but not for bromfenac. The two bromfenac treatments we re significantly superior to the two buprenorphine treatments. Signifi cantly more patients reported nausea with buprenorphine. There was evi dence of a ceiling effect for analgesia with bromfenac.