D. Carroll et al., ORAL BROMFENAC 10 AND 25 MG COMPARED WITH SUBLINGUAL BUPRENORPHINE 0.2 AND 0.4 MG FOR POSTOPERATIVE PAIN RELIEF, British Journal of Anaesthesia, 71(6), 1993, pp. 814-817
The aim of this single-dose, randomized positive control, double-dummy
, double-blind parallel group study was to compare oral bromfenac 10 a
nd 25 mg with sublingual buprenorphine 0.2 and 0.4 mg for treatment of
postoperative pain. We studied 91 patients with moderate or severe pa
in after general surgical or orthopaedic operations, using pain intens
ity, pain relief, adverse effect, mood and sedation outcomes. There wa
s a significant analgesic dose-response for buprenorphine, showing stu
dy sensitivity, but not for bromfenac. The two bromfenac treatments we
re significantly superior to the two buprenorphine treatments. Signifi
cantly more patients reported nausea with buprenorphine. There was evi
dence of a ceiling effect for analgesia with bromfenac.