Jl. Bembridge et al., COMPARISON OF PROPOFOL WITH ENFLURANE DURING HYPOTENSIVE ANESTHESIA FOR MIDDLE-EAR SURGERY, British Journal of Anaesthesia, 71(6), 1993, pp. 895-897
Forty patients undergoing middle ear surgery were allocated randomly t
o receive propofol induction and maintenance, or thiopentone induction
and enflurane maintenance for anaesthesia. Both groups also received
fentanyl, alcuronium, nitrous oxide and oxygen. If this did not reduce
systolic arterial pressure to 70 mm Hg, labetalol, glyceryl trinitrat
e (GTN), or both, was administered. Fifteen control patients had enflu
rane anaesthesia without hypotension. Pre- and postoperative psychomet
ric tests were performed in afl groups. The propofol group received si
gnificantly more labetalol (P = 0.014) and GTN (P = 0.004) than the en
flurane group. There was a greater increase in reaction times after op
eration in the study groups (P < 0.05) compared with controls. There w
as no difference between the propofol and enflurane groups in control
of arterial pressure, recovery from anaesthesia or psychometric testin
g.