RITANSERIN, IMIPRAMINE, AND PLACEBO IN THE TREATMENT OF DYSTHYMIC DISORDER

Fifty outpatients with dysthymic disorder (DSM-III) were divided by do uble-blind randomized assignment into three groups given ritanserin, i mipramine, and placebo, respectively. The trial was of 7 weeks' durati on; by week 6, imipramine was clearly superior to placebo, whereas by week 7, both drugs caused significantly more improvement than the plac ebo. Although imipramine had slightly greater efficacy than ritanserin , it also had significantly more side effects. This was particularly e vident in the higher dropout rate with imipramine. The efficacy and si de effect profile of ritanserin makes it well tolerated and acceptable with dysthymic patients who, although they do not respond as quickly as patients with major depressive disorder, do show significant improv ement, given sufficient time.