SINGLE-DOSE KINETIC-STUDY OF SARAFLOXACIN AFTER INTRAVASCULAR AND ORAL-ADMINISTRATION TO CANNULATED ATLANTIC SALMON (SALMO-SALAR) HELD IN SEA-WATER AT 12-DEGREES-C

Authors
MARTINSEN B SOHLBERG S HORSBERG TE BURKE M
Citation
B. Martinsen et al., SINGLE-DOSE KINETIC-STUDY OF SARAFLOXACIN AFTER INTRAVASCULAR AND ORAL-ADMINISTRATION TO CANNULATED ATLANTIC SALMON (SALMO-SALAR) HELD IN SEA-WATER AT 12-DEGREES-C, Aquaculture, 118(1-2), 1993, pp. 49-52
Citations number
6
Categorie Soggetti
Fisheries,"Marine & Freshwater Biology
Journal title
Aquaculture → ACNP
ISSN journal
00448486
Volume
118
Issue
1-2
Year of publication
1993
Pages
49 - 52
Database
ISI
SICI code
0044-8486(1993)118:1-2<49:SKOSAI>2.0.ZU;2-V
Abstract
The pharmacokinetic properties of sarafloxacin hydrochloride in cannul ated Atlantic salmon (Salmo salar) held in sea water were studied afte r intravascular and oral administration. Sarafloxacin was rapidly abso rbed, having a T-max at 6.25 h and a C-max of 0.35 mu g/ml. The elimin ation of sarafloxacin in cannulated salmon was relatively slow, t(1/2 beta) being 45.3 h in the group given the drug intravascularly. The bi oavailability was calculated to be 13.3%. The data diverged considerab ly between individuals, and the estimated parameters should be: interp reted with caution.