I. Koutroubakis et al., GRANULOMATOUS APPENDICITIS - A CLINICAL AND EPIDEMIOLOGIC-STUDY IN CRETE, European journal of gastroenterology & hepatology, 5(12), 1993, pp. 1061-1065
Objective: The aims of our study were: to provide an estimate of the i
ncidence of epithelioid granulomas of the appendix in Greece; to inves
tigate the relationship between granulomatous appendicitis and Crohn's
disease, and to estimate long-term prognosis. Methods: All pathology
reports of patients who underwent appendicectomy from 1986-1991 in the
prefecture of Heraklion were reviewed. In the cases with epithelioid
granulomas of the appendix, the clinical, histological and laboratory
features, as well as the clinical course, were recorded. Results: Four
cases with epithelioid granulomas of the appendix, with no known caus
e, were identified. Postoperative investigation of the alimentary trac
t in two of the patients was negative. Follow-up of the four patients
for 1.5-5 years (median 3.0 years) showed that all had been free of ga
strointestinal symptoms since the operation. Conclusion: Patients with
epithelioid granulomas of the appendix have an excellent long-term pr
ognosis and in most cases, granulomatous appendicitis seems to be unre
lated to Crohn's disease.