RISK-FACTORS FOR DEVELOPMENT OF PROTEINURIA BY TYPE-II (NON-INSULIN-DEPENDENT) DIABETIC-PATIENTS

1. Renal involvement in non-insulin dependent diabetes mellitus patien ts is the single most important cause of renal failure. The aim of thi s study was to evaluate the clinical features and to assess the risk f actors for the development of proteinuria by non-insulin dependent dia betic patients. 2. Risk factors (expressed as an odds ratio) were calc ulated by multiple logistic regression analysis taking into account ag e, sex, body mass index, known duration of diabetes, presence of arter ial hypertension, fasting plasma glucose, cholesterol and triglyceride s as independent variables and proteinuria as the dependent variable. Sixty-four normoalbuminuric (24-h albumin excretion rate <30 mu g/min, 27 females, mean age 53.7 years) and 53 proteinuric (24-h proteinuria >0.5g, 31 females, mean age 59.3 years) were studied. 3. Proteinuric patients were older, with a longer mean known duration of diabetes (12 .4 vs 5.6 years), higher mean fasting plasma glucose (214 vs 168 mg/dl ) and plasma creatinine (1.5 vs 1.1 mg/dl) and more frequently present ed diabetic retinopathy (94% vs 23%),peripheral neuropathy (94% vs 23% ) and arterial hypertension (73% vs 16%) than normoalbuminuric patient s. Age >50 years, body mass index >28.6 kg/m(2), known duration of dia betes >10 years, presence of arterial hypertension, and fasting plasma glucose >160 mg/dl were significantly and independently associated wi th development of proteinuria.