CLINICAL-EVALUATION OF TL-201 SPECT IN SUPRATENTORIAL GLIOMAS - RELATIONSHIP TO HISTOLOGIC GRADE, PROGNOSIS AND PROLIFERATIVE ACTIVITIES

We performed (TI)-T-201 SPECT and cell kinetic studies on 28 presurgic al patients with supratentorial gliomas by administering bromodeoxyuri dine (BUdR). All patients had surgery and had follow-up for more than 25 mo. In patients with grade IV glioma (198.1% +/- 32.8%, n = 10), th e (TI)-T-201 index, expressed as the count rate of the tumor site to t he count rate over the contralateral normal region, was significantly higher than that in patients with grade III glioma (140.5% +/- 15.1%, n = 4, p < 0.01) or low-grade glioma (104.1% +/- 22.6%, n = 14, p < 0. 001). A significant correlation was observed between the (TI)-T-201 in dex and BUdR-positive cells in excised tumor specimens (r = 0.67, p < 0.001). The (TI)-T-201 index of the 12 patients who died was higher th an those who survived (173.2% Versus 122.4%, p < 0.01). These results show the clinical utility of (TI)-T-201 brain SPECT in imaging suprate ntorial glioma and that the (TI)-T-201 index is representative of prol iferative activity of the tumor.