Sl. Ackerman et al., THE MINIMAL SELF-SUFFICIENT ELEMENT IN A MURINE G-RICH PROMOTER IS A LARGE ELEMENT WITH IMPERFECT DYAD SYMMETRY(C), Proceedings of the National Academy of Sciences of the United Statesof America, 90(24), 1993, pp. 11865-11869
The murine adenosine deaminase gene has a structurally archetypal TATA
A-box-deficient G + C-rich promoter. The three Spl binding sites of th
e promoter are neither necessary nor sufficient for promoter function.
Minimal basal promoter activity resides within a 48-bp element downst
ream of the Spl binding sites. This element shows an imperfect dyad sy
mmetry around the promoter's major transcriptional initiation site and
contains at least two nuclear protein binding sites. The distinctive
sequence characteristics and nuclear protein binding locations of this
element led us to propose a model for how such promoters may function
.