Oi. Kiselev et al., MOLECULAR MECHANISM OF ACTION OF ANTIVIRA L ADAMANTANE AGENTS, VESTNIK ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK, (3), 1993, pp. 10-15
Regions of possible interaction between remantadine and transmebrane M
2 protein are revealed by analysis of amino acid substitutions in rema
ntadine- and deutiforin-resistant influenza viruses. The major region
includes 5-6 amino acid residues at position 25-31, partially involvin
g the premembrane region and the first position of a hydrophobic membr
ane-associated domain. The proposed model action of remantadine and it
s derivatives suggests that remantadine is included into the cell memb
rane lipid bimolecular layer by its adamantane share and its positivel
y charged NH2-group is exposed to the cell surface. This allows remant
adine and its analogs to be regarded as molecular ''hindrances'' for v
iral particle decapsidation and budding.