MALIGNANT DISEASE APPEARING LATE AFTER OPERATION FOR T1 N0 NON-SMALL-CELL LUNG-CANCER

Occurrences of malignancy in 308 patients who were clinically free of cancer 60 months or more after surgical treatment of TI NO non-small-c ell lung cancer are summarized. At last report, 210 patients remained alive with no evidence of malignant disease, 43 patients died of nonma lignant causes, and 55 patients had 59 occurrences of malignant diseas e. Late lung cancer recurrence was observed in 22 patients (concurrent with nasopharyngeal cancer in one patient and with laryngeal cancer i n one patient). Metachronous second lung cancer was noted in 20 patien ts (including concurrent colon cancer in one patient and metastatic re currence in one patient). Other nonpulmonary malignant tumors appeared in 13 patients. Including second lung cancer, 25 cancers of aerodiges tive epithelium were observed in 23 patients. The malignancy-free surv ival advantage for patients with squamous cancer observed until 60 mon ths after resection was not sustained at 60 months and beyond. At the time of last follow-up, 84 patients (27 %) had died, 43 were free of m alignancy, arid 41 had malignancy (14 patients were alive with maligna ncy and 210 with no evidence of disease). These data reinforce two con clusions: (1) The probability of lung cancer recurrence or appearance of new lung cancer 5 years or more after successful operation in this select subpopulation of patients with lung cancer is of concern. (2) T he malignancy-free survival advantage of patients with squamous cancer disappears after 5 years.