B. Richterruoff et Dh. Wolf, PROTEASOME AND CELL-CYCLE - EVIDENCE FOR A REGULATORY ROLE OF THE PROTEASE ON MITOTIC CYCLINS IN YEAST, FEBS letters, 336(1), 1993, pp. 34-36
The cell cycle of eukaryotic cells is strictly regulated. This regulat
ion is performed by a serine/threonine kinase. The different functions
of this kinase in the cell cycle are modulated by different cyclins,
which fluctuate in concentration ('cycle') during the different stages
of the cell cycle. Using yeast as a model organism we show here that
the activity of the multifunctional proteinase, the proteasome, is dir
ectly connected to the function of the mitotic cyclin Clb2. Our studie
s indicate that the proteasome is the proteolytic regulator of this cy
clin and thus a central regulator of the cell cycle.