Cm. Robinson et al., NONSTEROIDAL ANTIINFLAMMATORY DRUGS, PERIOPERATIVE BLOOD-LOSS, AND TRANSFUSION REQUIREMENTS IN ELECTIVE HIP-ARTHROPLASTY, The Journal of arthroplasty, 8(6), 1993, pp. 607-610
A study of 160 elective total hip arthroplasties revealed that those p
atients receiving nonsteroidal antiinflammatory drugs (NSAIDs) in the
preoperative period had a significantly increased perioperative blood
loss and transfusion requirement when compared with a control group re
ceiving other forms of analgesia for their osteoarthritis. The results
suggest that NSAIDs are implicated in increasing the operative blood
loss in these patients. The range of increased blood loss varied from
1.57 to 2.08 times the blood loss in the control group, and this effec
t was seen when the operation was carried out under spinal as well as
when under general anesthesia.