PHYSICOCHEMICAL PROPERTIES OF 2-METHYLTHIO-4-METHYLPHENOL, A MODEL-COMPOUND OF THE NOVEL COFACTOR OF GALACTOSE-OXIDASE

Authors
ITOH S HIRANO K FURUTA A KOMATSU M OHSHIRO Y ISHIDA A TAKAMUKU S KOHZUMA T NAKAMURA N SUZUKI S
Citation
S. Itoh et al., PHYSICOCHEMICAL PROPERTIES OF 2-METHYLTHIO-4-METHYLPHENOL, A MODEL-COMPOUND OF THE NOVEL COFACTOR OF GALACTOSE-OXIDASE, Chemistry Letters, (12), 1993, pp. 2099-2102
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
12
Year of publication
1993
Pages
2099 - 2102
Database
ISI
SICI code
0366-7022(1993):12<2099:PPO2AM>2.0.ZU;2-X
Abstract
Physicochemical properties of 2-methylthio-4-methylphenol (1) were exa mined in order to obtain information about the nature of the newly fou nd cofactor of galactose oxidase. Electrochemical studies and theoreti cal calculations indicated that the methylthio group works as an elect ron-withdrawing substituent to stabilize the radical species (one-elec tron oxidation state) of 1. The absorption spectrum obtained by the pu lse radiolysis of 1 was very close to that of the oxidized apoenzyme.