PREPARATION OF CHIRAL 1,2-ALKANEDIOLS WITH BAKER YEAST-MEDIATED OXIDATION

Authors
KOMETANI T MORITA Y FURUI H YOSHII H MATSUNO R
Citation
T. Kometani et al., PREPARATION OF CHIRAL 1,2-ALKANEDIOLS WITH BAKER YEAST-MEDIATED OXIDATION, Chemistry Letters, (12), 1993, pp. 2123-2124
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
12
Year of publication
1993
Pages
2123 - 2124
Database
ISI
SICI code
0366-7022(1993):12<2123:POC1WB>2.0.ZU;2-E
Abstract
(S)-1,2-Alkanediols, which were the opposite configuration to those pr oduced by baker's yeast-mediated bioreduction of corresponding 1-hydro xy-2-alkanones, were prepared by baker's yeast-mediated oxidation. Tre atment Of racemic 1,2-alkanediols with baker's yeast under the aerobic condition followed by removal of the corresponding 1-hydroxy-2-alkano nes, which were produced by enantioselective oxidation of (R)-1,2-alka nediols, afforded (S)-1,2-alkanediols.