This paper deals with designing of cryogenic distillation systems for
the separation of hydrogen isotopes in a thermonuclear fusion process.
The design must minimize the tritium inventory in the distillation co
lumns and satisfy the separation requirements. This induces the optimi
zation of both the structure and the operating conditions of the colum
ns. Such a problem is solved by use of a Mixed-Integer NonLinear Progr
amming (MINLP) tool coupled to a process simulator. The MINLP procedur
e is based on the iterative and alternative treatment of two subproble
ms : a NLP problem which is solved by a reduced-gradient method, and a
MILP problem, solved with a Branch and Bound method coupled to a simp
lexe. The formulation of the problem and the choice of an appropriate
superstructure are here detailed, and results are finally presented, c
oncerning the optimal design of a specific isotope separation system.