Citation
Ai. Clarkson et al., PILOT-SCALE VERIFICATION OF BIOPROCESS MODELS, Computers & chemical engineering, 18, 1994, pp. 190000651-190000655
Citations number
11
Categorie Soggetti
Computer Application, Chemistry & Engineering","Engineering, Chemical","Computer Science Interdisciplinary Applications
Journal title
ISSN journal
00981354
Volume
18
Year of publication
1994
Supplement
S
Pages
190000651 - 190000655
Database
ISI
SICI code
0098-1354(1994)18:<190000651:PVOBM>2.0.ZU;2-K
Abstract
This paper describes how pilot-scale verification trials have improved
the accuracy of process models used in the simulation of a process fo
r the recovery and purification of an intracellular enzyme, alcohol de
hydrogenase (ADH) from packed yeast. The trials have highlighted the u
nit operations where improvements in the models are required for impro
ved accuracy. The effects of process perturbations are also used to ex
amine the robustness of the predictive models.