N. Oi et al., DIRECT SEPARATION OF ALCOHOL ENANTIOMERS BY GC WITH CHIRAL STATIONARYPHASES BONDED TO AMINOSILICONE OIL, Bunseki Kagaku, 42(12), 1993, pp. 801-804
It was found that two chiral stationary phases, the copper(II) complex
of -bis(2-butoxy-5-t-butylphenyl)-3-phenyl-1-propanol [I] and N-3,5-d
initrobenzoyl-(D)-phenylglycine bended to the amino silicone oil [II],
are very effective for the direct separation of alcohol enantiomers b
y gas chromatography. Various racemic aliphatic alcohols and diols wer
e well resolved using a fused-silica capillary column coated with 10%
phase[I] in amino silicone oil; racemic aromatic alcohols were well re
solved using a column coated with phase[II]. Although phase[I] is rath
er unstable at higher column temperatures than 70 degrees C, phase[II]
shows good enantioselectivity at 180 degrees C. The joint use of thes
e two chiral stationary phases ([I] and [II]) is very valuable for the
direct enantiomer separation of a wide range of racemic alcohols by g
as chromatography.