DIRECT SEPARATION OF ALCOHOL ENANTIOMERS BY GC WITH CHIRAL STATIONARYPHASES BONDED TO AMINOSILICONE OIL

It was found that two chiral stationary phases, the copper(II) complex of -bis(2-butoxy-5-t-butylphenyl)-3-phenyl-1-propanol [I] and N-3,5-d initrobenzoyl-(D)-phenylglycine bended to the amino silicone oil [II], are very effective for the direct separation of alcohol enantiomers b y gas chromatography. Various racemic aliphatic alcohols and diols wer e well resolved using a fused-silica capillary column coated with 10% phase[I] in amino silicone oil; racemic aromatic alcohols were well re solved using a column coated with phase[II]. Although phase[I] is rath er unstable at higher column temperatures than 70 degrees C, phase[II] shows good enantioselectivity at 180 degrees C. The joint use of thes e two chiral stationary phases ([I] and [II]) is very valuable for the direct enantiomer separation of a wide range of racemic alcohols by g as chromatography.