SEROLOGICAL INVESTIGATION INTO THE ASSOCIATION BETWEEN STREPTOCOCCUS-BOVIS AND COLONIC-CANCER

Aims-To determine if there was an increase in antibody titre to Strept ococcus bovis in patients with colonic cancer, and if this might be a useful marker of the presence for colonic cancer. Methods-Serum sample s from 16 patients and 16 age matched controls were tested by immunobl ot and enzyme linked immunosorbent assay (ELISA) against antigen prepa rations from two strains of S bovis and one strain of Enterococcus fae calis. Results-No distinction between cancer patients and controls cou ld be made using immunoblots. ELISA did show an increase in antibodies to S bovis, but there was a greater increase in antibodies to E faeca lis. The increase in antibody titres was greatest with antigens which had been treated with periodate, and was therefore thought not to be c aused by antibody to the shared group D carbohydrate antigen. Conclusi on-It may be possible to construct a test for the detection of colonic cancer based on the detection of antibody to S bovis or E faecalis, t hough considerable further development of this concept is required.