Pt. Wilmshurst et al., HISTOPLASMA ENDOCARDITIS ON A STENOSED AORTIC-VALVE PRESENTING AS DYSPHAGIA AND WEIGHT-LOSS, British Heart Journal, 70(6), 1993, pp. 565-567
A 40-year-old man with aortic stenosis and disseminated histoplasmosis
did not respond to treatment with itraconazole. Though there was no h
aemodynamic deterioration, valvar regurgitation, or embolic phenomena
a presumptive diagnosis of infective endocarditis was made. This was c
onfirmed at aortic valve replacement. Antifungal treatment was continu
ed for 18 months after valve replacement and serological tests for His
toplasma became progressively more negative during a three year follow
up.