SUMM. The genus Tsukamurella belongs to the family Nocardiaceae, and i
s an environmental saprophyte. The type species is Tsukamurella paurom
etabola. Its microbiological identification and differentiation from t
he other species containing mycolic acids can be difficult. There has
been a few cases of human infections reported, usually in patients wit
h special conditions, such as chronic lung pathology, immunosuppressio
n (leukemia, solid tumors, maybe HIV-infection) or the long-term use o
f indwelling catheters. The treatment of choice, despite the lack of a
dequate guidelines, is an antibiotherapy combining a beta-lactam and a
n aminoglycoside; catheter removal appears to be essential for cure.