Training in the responsible conduct of research in the biomedical scie
nces is on its way to being a standard component in the graduate biome
dical curriculum. Emphasis in this area has been catalyzed by certain
requirements for such training imposed by the National Institutes of H
ealth and by an increased awareness of relevant issues created by the
publicity and discussion of incidents of scientific misconduct. The au
thors describe the development and formalization of a course about the
responsible conduct of science for students in the biomedical discipl
ines at Virginia Commonwealth University. In addition, they discuss ge
neral considerations of course content important in teaching scientifi
c integrity; examine the use of published resource materials and docum
ents from professional societies, institutions, states, and the federa
l government as teaching tools; and describe the importance of case st
udies as vehicles for teaching scientific integrity.