MEASURING THE BURDEN OF SECONDARY INSULTS IN HEAD-INJURED PATIENTS DURING INTENSIVE-CARE

Primary traumatic brain damage may be compounded by secondary pathophy siological insults that can occur soon after trauma, during transfer t o hospital or subsequent treatment of the head-injured patient. The ai m of this prospective study was to quantify the burden of a wide range of secondary insults occurring after head injury and to relate these to 12-month outcome. In 124 adult head-injured patients studied during intensive care using a computerized data collection system, less-than -or-equal-to 14 clinically indicated physiological variables were meas ured minute-by-minute. Verified values falling outside threshold limit s for greater-than-or-equal-to 5 min, as defined by the Edinburgh Univ ersity Secondary Insult Grading scheme, were analysed by insult grade and duration. A greater incidence of secondary insults was detected th an previous studies have indicated. Insults were found in 91% of patie nts and occurred in all severities of head trauma, at all ages, and at every level of Injury Severity Score (ISS). The cumulative durations were much greater than previously recorded although 85% of the total t ime was at the least severe grade. Short duration insults were common. In 71 patients, in whom 8 insults could be assessed (intracranial pre ssure, arterial hypo- and hypertension, cerebral perfusion pressure, h ypoxemia, pyrexia, brady- and tachycardia), outcome at 12 months was a nalysed using logistic regression to determine the relative influence of age, admission Glasgow Coma Sumscore, ISS, pupil response on admiss ion, and insult duration on both mortality and morbidity. The most sig nificant predictors of mortality in this patient set were durations of hypotensive (p = .0064), pyrexic (p = .0 1 37), and hypoxemic (p = .0 244) insults. When good versus poor outcome was considered, hypotensiv e insults (p = .0118) and pupil response on admission (p = .0226) were significant.