Hl. Wang et al., EVALUATION OF FERRIC OXALATE AS AN AGENT FOR USE DURING SURGERY TO PREVENT POSTOPERATIVE ROOT HYPERSENSITIVITY, Journal of periodontology, 64(11), 1993, pp. 1040-1044
THE AIM OF THIS STUDY was to evaluate the effectiveness of a 6% ferric
oxalate solution applied during periodontal surgery to prevent post-o
perative tooth hypersensitivity. Twenty-five adult patients with simil
ar bilateral periodontal defects participated in this study. Data were
collected at baseline (1 week prior to surgery) and 1, 2, 4, and 6 we
eks following surgery. Sensitivity level was determined using the visu
al analog scale (VAS) with the following stimuli: 1) mechanical stimul
ation with a No. 23 dental explorer; 2) water at 50 degrees C; 3) ice;
and 4) electric pulp tester (EPT). Teeth were randomly assigned to ei
ther test (6% ferric oxalate in 0.9% saline) or control (0.9% saline)
groups. Solutions were applied to the exposed root surfaces for 1 minu
te during surgery. Data were analyzed by repeated measures ANOVA, pair
ed t-test, and Pearson's correlation test. Results from this study dem
onstrated statistically significant reduction in the responses to ther
mal stimuli, especially cold, between groups treated with ferric oxala
te as compared to those treated with saline. For the cold test the dif
ference increased with time from baseline to 6 weeks. Statistically si
gnificant (P <0.05) differences in sensitivity to heat between groups
were also observed, but only at 2 and 4 weeks following surgery. There
were no differences at any time period between the test and control g
roups when tactile or EPT techniques were used. In addition, there was
no correlation between sensitivity and other clinical parameters. It
was concluded from this study that 6% ferric oxalate was effective in
reducing post-surgical cold sensitivity when applied during periodonta
l surgical procedures.