A TANDEM ENZYMATIC-HYDROLYSIS OF 3-ACETYLTHIO-2-METHYLPROPIONIC METHYESTER

Authors
TAI DF HUANG CC HUANG HY SHIH IL
Citation
Df. Tai et al., A TANDEM ENZYMATIC-HYDROLYSIS OF 3-ACETYLTHIO-2-METHYLPROPIONIC METHYESTER, Biotechnology letters, 15(12), 1993, pp. 1229-1232
Citations number
12
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
15
Issue
12
Year of publication
1993
Pages
1229 - 1232
Database
ISI
SICI code
0141-5492(1993)15:12<1229:ATEO3M>2.0.ZU;2-5
Abstract
Enzymatic hydrolysis of racemic 3-acetylthio-2-methylpropionic methyl ester catalyzed by bovine pancreatic protease and Mucor javanicus lipa se showed opposite enantioselecivity. A tandem hydrolysis of the ester catalyzed by these two enzymes gives enantiomerically enriched (S)-3- acetylthio-2-methylpropionic acid, a building block of captopril.