HYDROXYCHLOROQUINE TOXICITY DESPITE NORMAL DOSE THERAPY

The risk of retinopathy associated with the use of hydroxychloroquine is said to be nullified if the dosage recommendations are followed str ictly. In this case report, we describe an elderly patient with rheuma toid arthritis who had bilateral maculopathy, presumably secondary to hydroxychloroquine therapy, despite a dosing regimen within therapeuti c guidelines. We believe special attention should be given to elderly patients who are being treated with hydroxychloroquine because their r etinal pigment epithelium may be more susceptible to the toxic effects of this drug.