THE SUPEROXIDE SCAVENGING ACTIVITY OF DIHYDROQUINOLINE TYPE DERIVATIVES (CH402 AND MTDQ-DA)

Electron paramagnetic resonance/spin trapping studies were applied, to verify the superoxide radical scavenging activity of two non-toxic, w ater soluble dihydroquinoline type antioxidants, CH402 (Na-2, 2-dimeth yl-1,2-dihydroquinoline-4-yl methane sulphonate and MTDQ-DA (6,6-methy lene bis 2,2-dimethyl-4-methane sulphonic acid: Na-1,2-dihydroquinolin e). Results were compared with other indirect methods such as the ampe rometric, spectrophotometric and luminometric methods, respectively. B oth dihydroquinoline type antioxidants scavenged superoxide in vitro s pecifically. MTDQ-DA scavenged superoxide an order of magnitude faster than CH-402. Neither CH402 nor MTDQ-DA affected the hypoxanthine/xant hine oxidase superoxide generating system, nor did they inhibit xanthi ne oxidase directly.